Endothelial Dysfunction Induced by Ischemia and Reperfusion Pentaerythrityl Tetranitrate and Nitroglycerin, but not Isosorbide Mononitrate, Prevent
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چکیده
Saverio Dragoni, Tommaso Gori, Monica Lisi, Giuseppe Di Stolfo, Andrea Pautz, Hartmut Endothelial Dysfunction Induced by Ischemia and Reperfusion Pentaerythrityl Tetranitrate and Nitroglycerin, but not Isosorbide Mononitrate, Prevent Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2007 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.107.149278 2007;27:1955-1959; originally published online July 19, 2007; Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/27/9/1955 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion.
BACKGROUND Short term exposure to nitroglycerin (GTN) has protective properties that are similar to ischemic preconditioning. Whether other organic nitrates such as pentaerithrityl tetranitrate (PETN) and isosorbide mononitrate (ISMN) have similar protective effects has not been explored. METHODS AND RESULTS In a randomized, parallel, double blind, controlled trial, 37 healthy young volunteer...
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Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator effects improving symptoms in patients with acute and chronic congestive heart failure, stable coronary artery disease, acute coronary syndromes, or arterial hypertension. The mechanisms underlying vasodilation inc...
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rganic nitrates are still quite frequently used for the reatment of acute and chronic angina, and acute and hronic congestive heart failure. When given acutely, their ffectiveness is undisputable; however, their long-term effiacy is substantially limited due to the development of olerance (1) and the induction of endothelial dysfunction (2), parameter that has prognostic significance in patient...
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